Not only does the over-the-counter-pharmaceutical-management of pain increase heart attacks and stroke risks, but gastrointestinal toxicity is a big danger of NSAID use as well.
On the basis of conservative figures "...the annual number of hospitalizations in the United States for serious gastrointestinal complications is estimated to be at least 103,000. At an estimated cost of $15,000 to $20,000 per hospitalization, the annual direct costs of such complications exceed $2 billion."
On the basis of conservative figures "...the annual number of hospitalizations in the United States for serious gastrointestinal complications is estimated to be at least 103,000. At an estimated cost of $15,000 to $20,000 per hospitalization, the annual direct costs of such complications exceed $2 billion."
Theis emphasis of cost fails to recognize the more important mortality rate for patients hospitalized for NSAID-induced upper gastrointestinal bleeding which is reported by Wolfe et. al. as 5 to 10 percent.
Wolfe further reports that "It has been estimated conservatively that 16,500 NSAID-related deaths occur among patients with rheumatoid arthritis or osteoarthritis every year in the United States. This figure is similar to the number of deaths from the acquired immunodeficiency syndrome [AIDS] and considerable greater than the number of deaths from multiple myeloma, asthma, cervical cancer, or Hodgkin's disease."
NSAIDs cause problems in the entire gastrointestinal tract, ranging from peptic ulcers to small intestine and colon problems. In a study to determine the safety of low-dose daily aspirin therapy in the gastrointestinal tract, it was concluded that the safety of even 10 mg of daily aspirin is questionable, which is far below the typical baby aspirin dosage of 80 mg. The problems do not stop in the gut; the breakdown of the gut mucous membranes leads to leaky gut syndrome with all of its ramifications, including liver toxicity.
http://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138
http://www.ncbi.nlm.nih.gov/pubmed/10369853
Wolfe further reports that "It has been estimated conservatively that 16,500 NSAID-related deaths occur among patients with rheumatoid arthritis or osteoarthritis every year in the United States. This figure is similar to the number of deaths from the acquired immunodeficiency syndrome [AIDS] and considerable greater than the number of deaths from multiple myeloma, asthma, cervical cancer, or Hodgkin's disease."
NSAIDs cause problems in the entire gastrointestinal tract, ranging from peptic ulcers to small intestine and colon problems. In a study to determine the safety of low-dose daily aspirin therapy in the gastrointestinal tract, it was concluded that the safety of even 10 mg of daily aspirin is questionable, which is far below the typical baby aspirin dosage of 80 mg. The problems do not stop in the gut; the breakdown of the gut mucous membranes leads to leaky gut syndrome with all of its ramifications, including liver toxicity.
http://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138
http://www.ncbi.nlm.nih.gov/pubmed/10369853
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